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Biological redox reactions catalyzed by H 2 O 2 or organic hydroperoxide typically involve the oxidation of thiol groups on cysteines with a low pK a , allowing the cysteine thiol group (SH) to exist as a thiolate anion (S )

The second group includes the organic anion transporting polipeptide proteins OATP which act as GSH/OA- exchanger

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doi: 10.1126/scitranslmed.3007116 48 SarabhaiTPeterCBrAKWindolfJReljaBWesselborgSet al

309,422 However, peptide carriers and their cargos often become trapped in acidified endosomes, preventing their entry into the cytoplasm, nucleus, and other subcellular compartments

it means that Wnt signaling increased [101]